6 in 10
U.S. adults have at least one chronic disease. Four in 10 have two or more. Chronic disease is the leading driver of death and disability in the United States.
CDC, National Center for Chronic Disease Prevention and Health PromotionWhy the immune system?
Immune complexity sits under health, disease, and most monitoring
The human immune system is a network of metabolism, gene regulation, signal transduction, and many interacting cell types. The figures below come from published sources.
1 in 5
Global deaths were associated with sepsis in 2017 (about 11 million of 56 million deaths that year) in a peer-reviewed global burden analysis.
Rudd et al., The Lancet 395 (10219), 200–211 (2020)485
Inborn errors of immunity were classified in the 2022 International Union of Immunological Societies update, covering monogenic disorders of the immune system.
Tangye et al., Journal of Clinical Immunology 42, 1473–1507 (2022)What current monitoring still struggles to show
Even well-validated laboratory tests are usually interpreted as snapshots. The open question ImmuNovus is built around is trajectory: whether an inspectable mechanistic view can help clinicians see how immune state may be changing early enough to inform the next decision. That is a research aim, not a claim that routine tests are worthless or that a deployed clinical product exists today.